DACLATASVIR
Daclatasvir dihyhrochloride
Daclatasvir dihyhrochloride is available as a tablet form which contains anti viral activity that prohibits the NS5A domain of the hepatitis C virus (HCV) Generally it is used in combinational therapy, with other anti viral agents to cure chronic hepatitis C.
Mechanism of action :
Daclatasvir act as hepatitis C NS5A inhibitor. It is also a P-Glycoprotein Inhibitor, organic anion transporting polypeptide 1B1, 1B3 inhibitor and breast cancer resistance protein inhibitor. It worked by blocking the viral replication leads to chain termination.
Side effects :
• Chest pain or discomfort
• lightheadedness, dizziness, or fainting
• slow or irregular heartbeat
• unusual tiredness
More common :
• Headache
• nausea
Less common :
• Diarrhea
Nervous system :
• Headache
• Dizziness
• migraine
• somnolence
Dermatologic :
• Headache
• Erythema
• Pruritus
• rash,
dry skin
• alopecia
• Erythema multiforme
Psychiatric :
• Insomnia
• irritability
• Depression
• anxiety
Hematologic :
• Anemia
• neutropenia
• Thrombocytopenia
• decreased hemoglobin
• Headache
• Eosinophilia
Respiratory :
• Cough, Nasopharyngitis
• dyspnea, Exertional dyspnea
• nasal congestion
• upper respiratory tract infection
Gastrointestinal :
• Diarrhea,nausea
• Upper abdominal pain
• abdominal pain
• constipation, flatulence
• gastro esophageal reflux disease
• dry mouth, vomiting,
• elevated lipase
Musculoskeletal :
• Myalgia
• arthralgia
• Back pain
Metabolic :
• Decreased appetite
Cardiovascular :
• Symptomatic bradycardia
• heart block
• cardiac arrhythmias
Hepatic :
• Increased ALT
• increased AST
• increased total bilirubin
• Hepatitis B reactivation
Genitourinary :
• Urinary tract infection
Ocular :
• Dry eye
Dosage and administration :
Daclatasvir not used alone, it is combined with Sofosbuvir.
Genotype I :
Without cirrhosis and compensated cirrhosis: Daclatasvir with Sofosbuvir for 12 weeks Decompensated cirrhosis: Daclatasvir with Sofosbuvir combined with ribavirin for 12 weeks.
Genotype III :
Without cirrhosis: Daclatasvir with Sofosbuvir for 12 weeks Compensated or decompensated cirrhosis: Daclatasvir with Sofosbuvir combined with ribavirin for 12 weeks.
Precaution :
It should not use alone; it must be combined with Sofosbuvir.
Storage :
It should be store at room temperature, 68°F to 77°F (20°C to 25°C).
Product Features
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