Erlonat (Erlotinib), (A metastatic Non-small cell lung cancer drug)


Erlonat (Erlotinib), it is a hydrochloride salt of quinazoline derivative with anti-tumor activity.
Erlonat exhibits its activity by binding to intracellular catalytic region of EGFR (epidermal growth factor receptor) tyrosine kinase.
Therefore signal transduction will be inhibited and leads to cell death.

How erlonat done its work:

Erlonat involved in cell lysis by inhibiting the signal transduction of cancer cells through epidermal growth factor receptors, which are present on the surface of the cancer cells and also in normal cells.
Tyrosine kinase inhibitors proceed its action on EGFR which may leads to block angiogenesis and cellular multiplication (cell division).

Erlonat indicated for;

Erlonat is primarily used for the treatment of;
Advance or metastatic non small cell lung cancer.
Pancreatic cancer by combining with gemcitabine.

Erlonat Contraindicated to

Pregnancy and women who become pregnant
Breast feeding
Hypersensitivity reaction


About erlonat:

Drug name: Erlotinib
Type of drug: Tyrosine kinase inhibitor or Anti-neoplastic agent
Used for: metastatic non-small cell lung cancer & pancreatic cancer
Also known as: Erlonat
Available strength: 150MG
Mfg: Natco

Pregnancy and lactation:

The pregnancy category of Tablet erlonat comes under ā€œDā€
Erlonat should not be recommended in pregnancy and lactation period.
Erlonat cause harm to the unborn babies


The storage condition of Erlonat tablets container should be kept at 25oC (77oF); excursion between 15oC to 30oC
Container should be keep away from moisture, heat and light.





Erlonat precaution in case of;


Interstitial lung disease

Renal failure


Erlonat precaution in case of;

Gastrointestinal perforation

Bullous and exfoliative skin disorders

Cerebrovascular accident

Erlonat precaution in case of;

Ocular disorders


Embryo fetal toxicity



Pharmacokinetic action of Erlonat

60% of drug absorbed after oral administration; the peak plasma concentration of the drug occurs within 4 hours The bioavailability of the drug 60% but increased by food to 100%


Nearly 93% of drug bound to the human plasma protein.



Pharmacokinetic action of Erlonat

Most of the drug metabolized in liver with the help of cytochrome isoenzymes like CYP3A4 to lesser extent CYP1A4.


The elimination routes are feces and urine. The half life is around 36 hours.




Avoid concomitant with proton pump inhibitors. Erlonat should be administered 10 hours after the H2 receptor antagonist and at least 2 hours before the next dose of H2 receptor antagonist.

Missed dose:

In case of missed dose, the patient should be advice by taking missed tablet within the period of next dose; otherwise the dose will be skipped and follow the regular dosing schedule. Do not double the dose



Erlonat interacts with some drugs;

Avoid these concomitants (combinations)

Aprepitant: increase the serum concentration of CYP3A4 substrates

Bosentan: depletes the serum concentration of CYP3A4 substrates

Ceritinib: increase the serum concentration of CYP3A4 substrates

Ciprofloxacin: elevate the serum concentration of Erlotinib

Conivaptan: increase the serum concentration of CYP3A4 substrates

CYP3A4 inducers (moderate or strong) decrease the serum concentration of Erlotinib and CYP3A4 inhibitors (moderate and strong) decrease the metabolism and increase the serum concentration respectively

Dabrafenib, dasatinib, deferasirox, Enzalutamide, proton pump inhibitors, H2 receptor antagonist etc


Erlonat adverse conditions;

Cardiovascular: chest pain, peripheral edema

Central nervous system: fatigue, headache, dizziness, insomnia, paresthesia,

Dermatologic: skin rash, Pruritus, paronychia, alopecia, acne, vulgaris

GIT: diarrhea, anorexia, nausea, loss of appetite, vomiting, stomatitis, abdominal pain

Genitourinary: urinary tract infection

Hematologic: anemia

Muscle: weakness, back pain, arthralgia, musculoskeletal pain

Ophthalmic: conjunctivitis, keratoconjuctivitis sicca

Pulmonary: cough, dyspnea

Miscellaneous: fever


millionpharma.biz is a fully licensed and regulated pharmacy, takes all precautions to strictly abide by the laws and regulations set forth in the dispensing of prescription medications. By placing the order for your prescription medicines, you acknowledge and accept the following terms regarding the purchase of any prescription medicines.

millionpharma.biz will not dispense any prescription medication without a valid prescription from a licensed physician.

If you are ordering prescription medication(s), you hereby confirm that you will send us a scanned copy of your valid prescription(s) via email, fax, Whatsapp, or by post, and this prescription shall then be subject to the scrutiny of and approval by our qualified Pharmacists

The drug information provided in the millionpharma.biz is for informative purposes only and this Website is not intended to provide diagnosis, treatment or medical advice. We are not liable for any adverse effects or harm to you as a result of your reliance on the information in the Website.

millionpharma.biz requires either the User or Customer or the Caregiver to confirm he/she is completely aware of the indications, side effects, drug interactions, effects of missed dose or overdose of the medicines he/she orders from us. It is imperative to seek professional advice from your physician before purchasing or consuming any medicine from millionpharma.biz

millionpharma.biz is a Caregiver can order prescription medicines on your behalf.


This information should not be used to decide whether or not to take this Product or any other medicine. Only the healthcare provider has the knowledge and training to decide which medicines are right for a specific patient. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this Product . It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this product. This information is not specific medical advice and does not replace information you receive from the healthcare provider. You must talk with the healthcare provider for complete information about the risks and benefits of using this product.