• millionhealthpharmaceuticals@gmail.com
  • +91-9940472902

Geftinat


Geftinat is pharmacologically sorted as tyrosine kinase inhibitor which may intrudes on the signal transduction through EGFR in tumor cells.
Geftinat tablets are containing a hostile to tumor specialist known as Gefitinib, which is synthetically delegated anilinoquinazoline subsidiary.
Geftinat tablets are doctor prescribed pharmaceutical which is utilized by the patients with substantial medicine proposed by therapeutic oncologist

GEFTINAT TABLETS INDICATED FOR;

Geftinat is principally utilized for treating progressed non small cell lung cancer in quiet whose tumor cells having EGFR exon 19 deletions or exon 21 substitutions.

HOW GEFTINAT TABLETS WORKS;

The reactant development of different tyrosine kinases including the EGFR get controlled by Gefitinib, which may completes up in prevention of tyrosine kinase subordinate tumor advancement
Gefitinib encounters with the uniting of ATP to the tyrosine kinase site of EGRF, through prohibiting receptor autophosphorylation and completing up in confinement of signal transduction.
Gefitinib also connected with the action of cell catch prompting and angiogenesis controlling.

How the body works for Geftinat tablets;;

Bioavailability of Gefitinib is 100% Time to maximium plasma concentration is Gefitinib is 3 to 7 hours after uptake of food.
Gefitinib is bound to human plasma protein by 90%. Gefitinib metabolism in liver aided by CYP3A4. Biotransformation of Gefitinib obtained by three pathway;
• Metabolism of N-propoxymorpholino group
• Demethylation of Methoxy substituent on quinazoline
• Oxidative defluorination of halogenated phenyl group
Excretion process of Gefitinib is occurs by hepatic metabolism. Gefitinib eliminated at 86% via feces & 4% via urine.
Half life of Gefitinib is 48 hours

geftinat
geftinat


Brand : Geftinat
Active substance :Gefitinib
Strength : 250mg
Mfg : Natco pharma
Pack :30 tablets

Buy Now

HOW TO USE GEFTINAT TABLETS;

The recommended dose of Geftinat is 250mg should be administered orally as single dose by taking with or without food.
If there should be an occurrence of patients neglect to take the Geftinat tablets orally, it ought to be dissolve in 4 to 8 ounces of water and blend well.
The blended arrangement ought to be managed orally or through naso gastric tube promptly.

Dose alteration:

Acute new commencement of or aggravation of pulmonary symptoms
Elevated AST & ALT levels
Worsening of ocular disorders
Skin reactions
Continue the Geftinat tablets therapy if toxicity grade changes from severe to grade I.

In case of this combination, the dose of Geftinat should be elevates to 500mg & continue as 250mg after discontinuing the CYP3A4 inducers..


Interstitial lung disease
Hepatotoxicity
GI perforation
Severe diarrhea
Ocular disorders
Cutaneous vasculitis

Bullous & exfoliative skin disorders
Other common side effects;
Nail disorders
Vomiting
Stomatitis
Loss of appetite

Conjunctivitis
Increased AST, ALT
Proteinuria
Cystitis
Hemorrhagic cystitis

Over Dosage

In case of over dosage; Patients should be provided with general supportive managements
Signs & symptoms should be monitored
Postpone or discontinue the Geftinat tablets.
Hemodialysis is not effective, because Gefitinib is widely bound to human plasma protein.

Drug Interaction

The co administration of Geftinat tablets with CYP3A4 inducers causes raises the digestion of Gefitinib and exhausts the Gefitinib plasma fixation.
In this condition, the dosage of Geftinat ought to be expanded to 500mg every day measurement at that point continuing as 250mg subsequent to ending the CYP3A4 inducers.
Geftinat joined with drugs influencing the pH causes diminishment in plasma concentration of Gefitinib. Stay away from the issue by managing Geftinat and gastric controllers sooner or later interims.
Proton pump inhibitors: Administer Geftinat 12 hours after the last measurements or 12 hours sooner the following dosage of proton pump inhibitor.
H2 receptor opponent: Administer Geftinat 6hours after the last dosage or 6 hours sooner the following measurements of H2 receptor adversary
Geftinat with warfarin causes change in prothrombin time and INR esteem, this may finishes up as drain.

WARNING

Skin issue: Geftinat tablet ought to be put off or ended amid serious skin responses.
Developing life fetal harmfulness: Geftinat is contraindicated to pregnancy, causes fetal mischief
GI perforation: Geftinat tablet ought to be for all time ceased amid this condition.
Diarrhea: In serious loose bowels condition, for all time suspend
Visual scatters: Ocular issue like corneal disintegration, conjunctivitis and dry eye condition, treatment ought to be ended.
Interstitial lung infection: Interrupt the Geftinat tablets and give steady measures.
Liver poisonous quality: Monitor the hepatic capacities and hepatic compounds levels. Geftinat tablets ought to be withheld or suspend the treatment in serious hepatic impedance condition.

PREGNANCY;

Pregnancy category of Gefitinib is D
Geftinat tablets are not used in pregnancy period. Avoid becoming pregnant during therapy.

LACTATION;

No breast feeding should be recommended.

PEDIATRICS;

The potency & effectivity of Gefitinib should not be evaluated in pediatric patients.

CONTRAINDICATIONS;

geftinat tablets are contraindicated to pregnancy & lactating women.
Some anaphylactic reactions are produced, if patients are contraindicated to the component of geftinat.

house

GEFTINAT MISSED DOSE

Missed dosage condition ought to be maintained a strategic distance from in the event that missed dosage happen, patients must get exhortation from medicinal oncologist and take after the guidelines.
Then again avoid the missed dosage and take after the normal dosing plan
Stay away from self medicine

house

STORAGE:

Store at 20°C- 25°C
Geftinat should use before the medicine expiry date.
Keep away the medicine from sight and reach of the medicine.
Geftinat should be disposed in proper way, don’t throw away via waste water or household waste.

PRESCRIPTION


million-pharmacy.com is a fully licensed and regulated pharmacy, takes all precautions to strictly abide by the laws and regulations set forth in the dispensing of prescription medications. By placing the order for your prescription medicines, you acknowledge and accept the following terms regarding the purchase of any prescription medicines.

million-pharmacy.com will not dispense any prescription medication without a valid prescription from a licensed physician.

If you are ordering prescription medication(s), you hereby confirm that you will send us a scanned copy of your valid prescription(s) via email, fax, Whatsapp, or by post, and this prescription shall then be subject to the scrutiny of and approval by our qualified Pharmacists

The drug information provided in the million-pharmacy.com is for informative purposes only and this Website is not intended to provide diagnosis, treatment or medical advice. We are not liable for any adverse effects or harm to you as a result of your reliance on the information in the Website.

million-pharmacy.com requires either the User or Customer or the Caregiver to confirm he/she is completely aware of the indications, side effects, drug interactions, effects of missed dose or overdose of the medicines he/she orders from us. It is imperative to seek professional advice from your physician before purchasing or consuming any medicine from million-pharmacy.com

million-pharmacy.com is a Caregiver can order prescription medicines on your behalf.




Disclaimer


This information should not be used to decide whether or not to take this Product or any other medicine. Only the healthcare provider has the knowledge and training to decide which medicines are right for a specific patient. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this Product . It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this product. This information is not specific medical advice and does not replace information you receive from the healthcare provider. You must talk with the healthcare provider for complete information about the risks and benefits of using this product. ,

Contact US




send your message

address

Portion 'A' First Floor,
Old No. 131, New No. 50,
Pedariyar Koil Street,
Seven Wells, Chennai - 600001.
Tamilnadu,India.

e-mail

millionhealthpharmaceuticals@gmail.com

+91-9940472902