(Anti-neoplastic drug)



BRAND: Geftinat
ACTIVE ingredients:Gefitinib
MANUFACTURED: Natco pharma
Package:30 tablets in a container
Category:Tyrosine kinase Inhibitor

Geftinat tablets

Geftinat (Gefitinib) is a signal transduction inhibitor. Geftinat is categorized as targeted therapy which means to target the epidermal growth factor receptor tyrosine kinase inhibitor

Geftinat is the prescription medicine; it should be used only for the patients who are having valid prescription from medical oncologist

Geftinat is a chemo drug, it should not be self medicated by the patients

Geftinat Geftinat ideally indicated for;

In Advanced or metastatic non-small cell lung cancer

Geftinat is used only after failure of both platinum based and taxane based chemotherapies

How to administer Geftinat tablets;

In Adults

Geftinat tablets are used in the conditions like advanced non-small cell lung cancer

The usual prescribed dose of Geftinat tablets are 250mg should be administer orally as a single dose with or without food

If patient found difficult to swallow the Geftinat tablets means, it should be dispersed in 4 to 8 ounces of plain uncarbonated water and drink the solution immediately

In Pediatric

The safety and efficacy of tablet Geftinat has not been fixed in pediatric patients

Dosage Modification

The safety and efficacy of tablet Geftinat has not been fixed in pediatric patients..
Elevation of Alt & AST.
Diarrhea, ocular disorders, skin reactions.
Acute onset or worsening pulmonary symptoms.

Permanently stop to take the Tablet Geftinat if patient having these conditions;

In case of concurrent use with strong CYP3A4 inducers;

Increase the dosage of Geftinat tablet to 500mg orally as a single dose, if no adverse reaction produces

Again restart to 250mg orally as a single dose after discontinuation of CYP3A4 strong inducers

Geftinat should not be taken with antacids to reduce the effect of gefitinib

  • Severe hepatic impairment
  • Confirmed interstitial lung disease
  • Persistent ulcerative keratitis
  • Gastrointestinal perforation

The safety and efficacy of tablet Geftinat has not been fixed in pediatric patients

Geftinat causes adverse effects;

<1% of people having chances to get;
  • Gastrointestinal perforation Ocular keratitis
  • Erythema multiforme
  • Dermatitis Bullous
  • Fatal hepatoxicity
  • Interstitial lung disease
  • Hyperbillirubemia, stomatitis
  • Corneal erosion
  • Aberrant eyelash growth
  • Nail disorders
10% of patients receiving Geftinat tablet having chance to get
  • Skin reaction
  • Diarrhea
  • Loss of appetite
  • Vomiting
  • Increased ALT
1-10% of patients having chance to get;
  • Elevation of AST,
  • Stomatitis,
  • Conjunctivitis,
  • Blepharitis, dry eye,
  • Nail disorders, diarrhea,
  • Increased bilirubin levels,
  • Loss of appetite,
  • Interstitial lung disease


Geftinat tablets are quietly absorbed after drug intake
Peak plasma concentration: not beyond 3-7 hours
Bioavailability of the drug is 60%


The Human plasma protein bound with Geftinat nearly 90%

The volume of distribution is 1400L


The metabolism of the drug Gefitinib occurs in liver.

Geftinat tablets are metabolized aided by cytochrome isoenzymes CYP3A4


The routes of elimination of metabolites

Feces 86%; Urine 4%

The terminal half life time of Geftinat tablet is 48 hours

Stop Getting Sick

Geftinat tablet should not be taken in the conditions;

Interstitial pneumonitis Lung fibrosis, liver problems, renal impairments, pregnancy & breastfeeding mothers

Drug interaction of Geftinat tablet; ;

These are some drugs which will interfere with serum concentration of cytochrome isoenzymes

H2 receptor antagonist and proton pump inhibitors: Concomitant with Geftinat, depletes the serum concentration of Gefitinib

Antacids: reduce the serum concentration of Gefitinib

Aprepitant: elevation of serum concentration of CYP3A4 substrates ;

Abiraterone acetate: raise the serum concentration of CYP2D6 substrates ;

Elevation the serum concentration of CYP2D6 substrates;

Geftinat elevates the anti-coagulant effect of vitamin K antagonist like warfarin
Asunaprevir, Bosentan, Ceritinib, cobicistat, conivaptan, CYP2D6 inhibitors (moderate and strong), CYP3A4 inducers (moderate and strong), CYP3A4 inhibitors (moderate and strong), Dabrafenib, darunavir, dasatinib, deferasirox, Enzalutamide, fosaprepitant ;

Contraindication occurs in Geftinat tablets ;

Geftinat tablets are contraindicated; ;

Geftinat tablets are contraindicated to pregnant ;

If patient taking Geftinat tablet, they may have chance to get anaphylactic reactions

Geftinat tablet in pregnancy and lactation condition; ;

Pregnancy category: C

Geftinat tablets should not endorsed in pregnancy condition, because it may cause fetal harm

Breast feeding is also not recommended, the metabolites of Geftinat tablets are excreted in human milk. It transfer through milk to babies and cause harm ;

Storage and handling: ;

The storage condition of Geftinat tablet;

Geftinat tablets container should be stored in cool and dry place

Keep out of reach from children and animal Protect from direct sunlight

Precautions and warning ;

Dermatological toxicity, Gastrointestinal effects, Hepatotoxicity, Ocular toxicity, Pulmonary toxicity, Hepatic toxicity.

Missed Dose

If patient fail to take Geftinat tablet, they must get advice from medical practitioner (oncologist) for administration of the missed dose within the time

Otherwise the missed dose should be skipped and follow the regular dosing schedule

Do not double the dose


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