Tenofovir alafenamide (TAF) as the successor of tenofovir disoproxil fumarate (TDF)
Tenofovir alafenamide is an investigational drug that is being studied for the treatment of HIV infection. It is also being studied for the treatment of chronic hepatitis B virus (HBV) infection.
Tenofovir alafenamide belongs to a class (group) of HIV drugs called nucleoside reverse transcriptase inhibitors (NRTIs). NRTIs block an HIV enzyme called reverse transcriptase. (An enzyme is a protein that starts or increases the speed of a chemical reaction.) By blocking reverse transcriptase, NRTIs prevent HIV from multiplying and can reduce the amount of HIV in the body.
Tenofovir alafenamide is currently being studied as a component of different investigational fixed-dose combination (FDC) drugs for the treatment of HIV infection. (FDC drugs include or more drugs in a single dosage form, such as a capsule or tablet.) Tenofovir alafenamide is being studied in the following combinations:
Darunavir/cobicistat/emtricitabine/tenofovir alafenamide bictegravir/emtricitabine/tenofovir alafenamide
Three FDC tablets are FDA-approved. The first FDC tablet contains elvitegravir/cobicistat/emtricitabine/tenofovir alafenamide (brand name: Genvoya) and was approved in November 2015.
The second FDC tablet contains emtricitabine/rilpivirine/tenofovir alafenamide (brand name: Odefsey) and was approved in March 2016.
The third FDC tablet contains emtricitabine/tenofovir alafenamide (brand name: Descovy) and was approved in April 2016. Descovy is also being studied in Phase III studies for HIV prevention.
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