Tenofovir Alafenamide (TAF)

TENOFOVIR ALAFENAMIDE (TAF)

Tenofovir alafenamide (TAF) as the successor of tenofovir disoproxil fumarate (TDF)

Description


Tenofovir alafenamide is an investigational drug that is being studied for the treatment of HIV infection. It is also being studied for the treatment of chronic hepatitis B virus (HBV) infection.

Tenofovir alafenamide belongs to a class (group) of HIV drugs called nucleoside reverse transcriptase inhibitors (NRTIs). NRTIs block an HIV enzyme called reverse transcriptase. (An enzyme is a protein that starts or increases the speed of a chemical reaction.) By blocking reverse transcriptase, NRTIs prevent HIV from multiplying and can reduce the amount of HIV in the body.

Tenofovir alafenamide is currently being studied as a component of different investigational fixed-dose combination (FDC) drugs for the treatment of HIV infection. (FDC drugs include or more drugs in a single dosage form, such as a capsule or tablet.) Tenofovir alafenamide is being studied in the following combinations:

Darunavir/cobicistat/emtricitabine/tenofovir alafenamide bictegravir/emtricitabine/tenofovir alafenamide

Three FDC tablets are FDA-approved. The first FDC tablet contains elvitegravir/cobicistat/emtricitabine/tenofovir alafenamide (brand name: Genvoya) and was approved in November 2015.

The second FDC tablet contains emtricitabine/rilpivirine/tenofovir alafenamide (brand name: Odefsey) and was approved in March 2016.

The third FDC tablet contains emtricitabine/tenofovir alafenamide (brand name: Descovy) and was approved in April 2016. Descovy is also being studied in Phase III studies for HIV prevention.

Prescription


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This information should not be used to decide whether or not to take this Product or any other medicine. Only the healthcare provider has the knowledge and training to decide which medicines are right for a specific patient. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this Product . It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this product. This information is not specific medical advice and does not replace information you receive from the healthcare provider. You must talk with the healthcare provider for complete information about the risks and benefits of using this product.

TENOFOVIR ALAFENAMIDE (TAF)

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